{"id":5131,"date":"2013-02-04T10:25:01","date_gmt":"2013-02-04T09:25:01","guid":{"rendered":"https:\/\/sesc.cat\/polycystic-kidney-in-a-pig\/"},"modified":"2022-03-24T19:01:24","modified_gmt":"2022-03-24T18:01:24","slug":"polycystic-kidney-in-a-pig","status":"publish","type":"post","link":"https:\/\/sesc.cat\/en\/polycystic-kidney-in-a-pig\/","title":{"rendered":"Polycystic kidney in a pig"},"content":{"rendered":"<p><strong>In a 6 months old hybrid pig a bilateral alteration was seen of the kidneys. These showed a loss of structure, with an obvious atrophy of the renal medulla and also, to a lesser extent, of the renal cortex parenchyma which presented with a <\/strong><strong>microcystic appearance<\/strong>.<!--more--> The urethers were significantly dilated and thickened.<\/p>\n<p>Histologically the renal parenchyma was almost entirely occupied by cysts lined by a simple epithelium, some of which contained glomerular structures more or less atrophied. In the interstitium fibrosis and a mild mononuclear inflammatory component could be appreciated. Scattered remnants of apparently normal (probably functional) renal parenchyma were also observed .<\/p>\n<p>The lesions observed point to a disturbance of normal renal development causing microcystic structures in virtually all of the renal cortex and a significant loss of renal medulla. Although this can&#8217;t be classified into known types of renal lesionin the differential diagnosis we may include:<\/p>\n<ul>\n<li><strong>Congenital polycystic kidney<\/strong>. Mutations in the PKD gene(polycystic kidney disease) can result in this type of lesion which is often hereditary.<\/li>\n<li><strong>Acquired Polycystic Kidney<\/strong> , perhaps as a result of a chronified interstitial inflammation or due to other causes that can trigger the onset of cysts (hypokalemia, some medications, etc).<\/li>\n<li><strong>Renal dysplasia<\/strong> (defect in the formation of nephrons), also congenital. But the focal presence of correctly formed nephrons makes this option less likely.<\/li>\n<\/ul>\n<div id=\"attachment_1369\" style=\"width: 586px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-1.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1369\" class=\" wp-image-6471 \" alt=\"Pale kidneys, with surface irregularities and atrophy of the medulla and the cortex. Histologically, prominent brown areas correspond to the fraction of normal renal parenchyma.\" src=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-1.jpg\" width=\"576\" height=\"432\" srcset=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-1.jpg 640w, https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-1-300x225.jpg 300w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><\/a><p id=\"caption-attachment-1369\" class=\"wp-caption-text\">Pale kidneys, with surface irregularities and atrophy of the medulla and the cortex. Histologically, prominent brown areas correspond to the fraction of normal renal parenchyma.<\/p><\/div>\n<div id=\"attachment_1370\" style=\"width: 586px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-2.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1370\" class=\" wp-image-6473 \" alt=\"Up close, a multitude of small cysts can be seen that give a spongy appearance to the parenchyma as well as the lack of renal medulla.\" src=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-2.jpg\" width=\"576\" height=\"432\" srcset=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-2.jpg 640w, https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-2-300x225.jpg 300w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><\/a><p id=\"caption-attachment-1370\" class=\"wp-caption-text\">Up close, a multitude of small cysts can be seen that give a spongy appearance to the parenchyma as well as the lack of renal medulla.<\/p><\/div>\n<div id=\"attachment_1368\" style=\"width: 630px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-4.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1368\" class=\"size-large wp-image-6469\" alt=\"Microscopically, all cysts were lined with simple epithelium and among them a few scattered traces of apparently normal renal parenchyma could be observed.\" src=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-4-800x600.jpg\" width=\"620\" height=\"465\" srcset=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-4-800x600.jpg 800w, https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-4-300x225.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><\/a><p id=\"caption-attachment-1368\" class=\"wp-caption-text\">Microscopically, all cysts were lined with simple epithelium and among them a few scattered traces of apparently normal renal parenchyma could be observed.<\/p><\/div>\n<div id=\"attachment_1367\" style=\"width: 630px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-3.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1367\" class=\"size-large wp-image-6467\" alt=\"Some of the cystic cavities contained a renal glomerulus. The interstitium showed fibrosis and in some areas mononucelar inflammatory infiltrate.\" src=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-3-750x600.jpg\" width=\"620\" height=\"496\" srcset=\"https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-3-750x600.jpg 750w, https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-3-300x240.jpg 300w, https:\/\/sesc.cat\/wp-content\/uploads\/2013\/02\/B-003-13-3.jpg 1280w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><\/a><p id=\"caption-attachment-1367\" class=\"wp-caption-text\">Some of the cystic cavities contained a renal glomerulus. The interstitium showed fibrosis and in some areas mononucelar inflammatory infiltrate.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>In a 6 months old hybrid pig a bilateral alteration was seen of the kidneys. These showed a loss of structure, with an obvious atrophy of the renal medulla and also, to a lesser extent, of the renal cortex parenchyma which presented with a microcystic appearance.<\/p>\n","protected":false},"author":6,"featured_media":8539,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[229,179],"tags":[393,407],"class_list":["post-5131","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kidney-porcine-2","category-porcine-2","tag-congenital-en","tag-kidney-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/posts\/5131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/comments?post=5131"}],"version-history":[{"count":0,"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/posts\/5131\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/media\/8539"}],"wp:attachment":[{"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/media?parent=5131"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/categories?post=5131"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sesc.cat\/en\/wp-json\/wp\/v2\/tags?post=5131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}