15/09/2015
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Bovino
6
Lesión negra subcutánea en el cuello de un ternero
Histológicamente se aprecia un cúmulo de material amorfo, acelular y eosinófilo rodeado por una reacción fibrosa y abundantes macrófagos cargados con gránulos intracitoplasmáticos de pigmento marrón. El nódulo linfático presenta una imagen histológica de normalidad. La lesión es compatible con un granuloma por cuerpo extraño, muy probablemente derivada de la administración percutánea de algún producto farmacológico de carácter oleoso.
La lesión, de coloración negruzca, estaba localizada en la región cervical caudal cerca del nódulo linfático preescapular.
Aspecto de la lesión en el tejido conectivo.
Detalle, de más cerca, del material negruzco. Hiperplasia leve del nódulo linfático preescapular.
6 comment(s)
Comment by Dr. Vinay Lomash at “Veterinary Pathology” Group in LinkedIN:
Clostridium novyi infection
Comment by Olakunle Tiamiyu at «Veterinary Pathology» Group in LinkedIN:
Could it be Clostridium or injected deposit of a drug?
Comment by Chretien Gielen at Veterinary Pathology Group in LinkedIN:
Iron injections are not unusual in veal calves, I am a practitioner and not very familiar with the histological findings, but an iron injection (ferrodextran) could cause the brown granules.
Best regards, Chretien
I totally agree with the histology being consistent with the diagnosis of an injection site reaction or foreign body granuloma. The brown amorphous granules are a bit unusual, although I have seen tetracyclines to this. Brown is more common with hemorrhage/hemosiderin either within an injection site or due to direct trauma. Most vaccines will have amorphous blue material- adjuvant, and other pharmaceutical agents, refractile material, basophilic or if steroid containing, acicular clefts. Any idea what possibly could have been injected? Best regards,
Dave
Thanks for your comment, Dave.
The impression of the pathologists is that the granules were of a lipidic nature (an oily excipient maybe). Tetracyclines have been suggested as a possibility or iron injection (less likely, in my opinion, since the granules have a different microscopic image),
Sadly we had no feedback on what had been injected in this case.
Cheers!
Comment by Chris Petzel at Ruminant Health, Nutrition and Production Professionals group in LinkedIn:
Depot injection of oxytetracycline?